ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : หัว

Activity : SERUM LDL LOWERING EFFECT

Solvent/Active Compound : 80% ethanol extract

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 10 mg/kg

Duration : 7 days

Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Ezetimibe

Dose/Conc.(drug) : 30 microgram/kg

Result : Positive

Remark : The combination of ezetimibe with garlic extract resulted in lowering of serum total body cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol along with increase in serum HDL-cholesterol after treatment.

Note : The animals were randomly divided into seven groups, six animals each. The dosage regimen was as follows: Group I-control, II-fructose (5 g/kg), III-fructose and ezetimibe, IV-fructose and garlic extract, V-fructose, Ezetimibe and garlic extract, VI-Ezetimibe (30 microgram/kg) and VII-garlic extract (10 mg/kg).

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