ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : หัว

Activity : DRUG INTERACTION

Solvent/Active Compound : Garlic extract (GE)

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 1.2 g/kg amikacin (AMK) was injected i.p., to rats as a single dose. Two dose of GE (300 mg) were given orally at the day of injgection and one day before injfection of AMK. The rats were sacrificed on the eighth day.

Duration : 8 days

Type of interaction : Pharmacodynamics

Interaction with drug : Amikacin

Dose/Conc.(drug) : -

Result : Positive

Remark : Result: GE significantly decreased the levels of nitric oxide, malondialdehyde and total antioxidant capacity. Furthermore, it increased the level of reduced glutathione. These changes are indicative for lower tissue damage and reduced free radical formation. These results were coinciding with the lower levels of urea, uric acid and creatinine (which were significantly elevated in amikacin treated groups). Semi-quantitative analysis of cellular infiltration, necrosis of tubular cells and tubular cellular damage indicated the protective effect of GE in reducing renal damage induced by amikacin.

Note : By using a rat model, Nigella sativa oil and Allium sativum extract efficiently ameliorated the renal toxic effect of amikacin.

---