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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 56 (M/F = 24/32)N(Treatment) : 1Sex : Both sexAge : 68.7 +/- 7.7 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : -Result : PositiveRemark : กระเทียม/น้ำมันกระเทียมมีฤทธิ์ลดความดันโลหิต จึงอาจเสริมฤทธิ์กับยาที่มีฤทธิ์ลดความดันโลหิต ทำให้ความดันโลหิตต่ำลงได้Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : garlic homogenateType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 125 mg/kg bw.Duration : 3 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: garlic in moderate dose (250 mg/kg) with added HCTZ possesses synergistic cardioprotective and antihypertensive properties against frutose- and isoproterenol-induced toxicities.Note : Experiment: Female Wistar albino rats were divided into nine groups. Group I: normal control, given ordinary drinking water, group II: fructose-fed (HF), group III: fructose plus hydrochlorothiazide (HCTZ) (10 mg/kg, p.o.) in the 6th week, group IV, V and VI were fed with fructose plus garlic homogenate (GH) 125, 250 and 500 mg/kg respectively orally for 3 weeks, group VII, VIII and IX were continued with fructose plus GH 125, 250 and 500 mg/kg respectively orally for 3 weeks as well as HCTZ (10 mg/kg, p.o.) in the 6th week. At the end of treatment, animals of all groups except group I were administered isoproterenol (ISO; 175 mg/kg s.c.) for 2 consecutive days.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : garlic homogenateType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 250 mg/kg bw.Duration : 3 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: garlic in moderate dose (250 mg/kg) with added HCTZ possesses synergistic cardioprotective and antihypertensive properties against frutose- and isoproterenol-induced toxicities.Note : Experiment: Female Wistar albino rats were divided into nine groups. Group I: normal control, given ordinary drinking water, group II: fructose-fed (HF), group III: fructose plus hydrochlorothiazide (HCTZ) (10 mg/kg, p.o.) in the 6th week, group IV, V and VI were fed with fructose plus garlic homogenate (GH) 125, 250 and 500 mg/kg respectively orally for 3 weeks, group VII, VIII and IX were continued with fructose plus GH 125, 250 and 500 mg/kg respectively orally for 3 weeks as well as HCTZ (10 mg/kg, p.o.) in the 6th week. At the end of treatment, animals of all groups except group I were administered isoproterenol (ISO; 175 mg/kg s.c.) for 2 consecutive days.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : garlic homogenateType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kg bw.Duration : 3 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Hydrochlorothiazide*/HCTZDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Results: garlic in moderate dose (250 mg/kg) with added HCTZ possesses synergistic cardioprotective and antihypertensive properties against frutose- and isoproterenol-induced toxicities.Note : Experiment: Female Wistar albino rats were divided into nine groups. Group I: normal control, given ordinary drinking water, group II: fructose-fed (HF), group III: fructose plus hydrochlorothiazide (HCTZ) (10 mg/kg, p.o.) in the 6th week, group IV, V and VI were fed with fructose plus garlic homogenate (GH) 125, 250 and 500 mg/kg respectively orally for 3 weeks, group VII, VIII and IX were continued with fructose plus GH 125, 250 and 500 mg/kg respectively orally for 3 weeks as well as HCTZ (10 mg/kg, p.o.) in the 6th week. At the end of treatment, animals of all groups except group I were administered isoproterenol (ISO; 175 mg/kg s.c.) for 2 consecutive days.
