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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 250 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : DiltiazemDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : DiltiazemDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
