Part Used : -
Activity : DRUG INTERACTION
Solvent/Active Compound : diallyl disulfide
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Cyclophosphamide*/CPM/CTX/CYT
Dose/Conc.(drug) : -
Remark : Type of experiment = maternal liver and placenta
Note : Diallyl disulfide (DADS) treatment significantly attenuated cyclophosphamide-induced developmental toxicity and oxidative damage in the maternal liver. DADS also significantly increased expression of CYP3A1 in the maternal liver placenta.