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AMARYLLIDACEAE Allium sativum L.

Synonym

none ...

Thai / English name

กระเทียม*

[1-5] of 5 article(s) found

หน้า 1

[1] USE OF DIETARY SUPPLEMENTS AND THEIR INTERACTIONS WITH PRESCRIPTION DRUGS IN THE ELDERLY.
LY J,PERCY L,DHANANI S
AM J HEALTH SYST PHARM 2002 Vol.59(18),1759-62 $20273 [Full]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Cross-section

N(Total) : 15
N(Treatment) : -

Sex : Both sex
Age : 78+-/6 yrs.

Route : Oral administration
Dose/Conc.(herb) : -

Duration : -
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Warfarin
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: Garlic + warfarin = Increased risk of bleeding (No. Potential or Possible Interactions = 1 of 45)

Note : Subject total: Subjects were veterans over the age of 65 years who are frail and have complex medical and psychosocial problems.

[2] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.2(),200-5 $29296 [Full]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound :

Type of experiment : human
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Warfarin
Dose/Conc.(drug) : -

Result : Positive

Remark : Single reports of increased bleeding time with lisinopril, warfarin.

Note : Data incomplete, data from review article.

[3] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.(2),200-5 $56391 [Full]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound :

Type of experiment : non specified
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Non-specified
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Warfarin
Dose/Conc.(drug) : -

Result : Positive

Remark : Reduction of CYP2E1 activity in humans and some animal species; no increase in CYP2B1/2 in humans. Mild inhibition of Pgp in vitro. Single reports of increased bleeding time with lisinopril, warfarin. Reduces bioavailability of the protease inhibitor saquinavir and to a lesser extent ritonavir. Appears safe with most drugs except saquinavir.

Note : Data from review, data incomplete.

[4] EFFECT OF HERBAL CONSUMPTION ON TIME IN THERAPEUTIC RANGE OF WARFARIN THERAPY IN PATIENTS WITH ATRIAL FIBRILLATION.
CHAN,HIU-TING;SO,LOK-TSUN;LI,SHEUNG-WAI;ET AL.
J CARDIOVASC PHARMACOL 2011 Vol.58(1),87-90 $59750 [Full]

Part Used : หัว
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Cross-section

N(Total) : 250
N(Treatment) : 201

Sex : Both sex
Age : 69+/-10 yrs.

Route : Oral administration
Dose/Conc.(herb) : Consumption of herbs at least 4 times per week

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Warfarin
Dose/Conc.(drug) : -

Result : Positive

Remark : Consumption of herbs at least 4 times per week was associated with suboptimal anticoagulation control with warfarin. Patients treated with warfarin should not only be aware of the intake of herbal drugs but also of foods with herbal ingredients such as garlic, ginger, and papaya.

Note : Patients with atrial fibrillation (AF) who were prescribed warfarin therapy for at least 6 months before the study were recruited from the medical and cardiac clinics.

[5] DRUG INTERACTIONS WITH GARLIC AND GINGER SUPPLEMENTS.
ABOU-DIWAN,CHARBEL;RITCHIE,JAMES.
HERBAL SUPPLEMENTS 2011 Vol.(),333-50 $60025 [Full]

Part Used : หัว
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Case report

N(Total) : 2
N(Treatment) : 2

Sex : Both sex
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Warfarin
Dose/Conc.(drug) : -

Result : Positive

Remark : The combination of warfarin and garlic extract caused an increase of clotting time and international normalized ratio (INR) in two separate case reports. These INR increases were attributed to garlic intake since no other medication changes had ocurred. In both cases, clotting time were roughly doubled.

Note : Data incomplete, data from review article

Part Used : หัว
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Cross-section

N(Total) : 1818
N(Treatment) : 25

Sex : Both sex
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Warfarin
Dose/Conc.(drug) : -

Result : Positive

Remark : In a recent cross -sectional point - of - care survey of 1818 patients, 25 cases involving coadministered warfarin/antiplatelet agent and garlic identified a potential clinically significant interaction between the anticoagulant/platelets and garlic.

Note : Data incomplete, data from review article

หน้า 1

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