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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : non specifiedType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : SaquinavirDose/Conc.(drug) : -Result : PositiveRemark : Reduction of CYP2E1 activity in humans and some animal species; no increase in CYP2B1/2 in humans. Mild inhibition of Pgp in vitro. Single reports of increased bleeding time with lisinopril, warfarin. Reduces bioavailability of the protease inhibitor saquinavir and to a lesser extent ritonavir. Appears safe with most drugs except saquinavir.Note : Data from review, data incomplete.
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 10 (M/F=4/6)N(Treatment) : 10Sex : Both sexAge : -Route : Oral administrationDose/Conc.(herb) : 3.6 mg of garlic caplets, twice dailyDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : SaquinavirDose/Conc.(drug) : -Result : PositiveRemark : Administration of garlic caplets containing 3.6 mg of garlic powdered extract, two times daily, decreased the plasma AUC by 51%, trough plasma concentration at 8 h (C8h) by 49% and Cmax by 54%. The AUC, C8h, and Cmax of saquinavir returned to 60-70% of its baseline values after the 10 - day washout period.Note : Data incomplete, data from review article
