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Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : aged garlic extractType of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 16N(Treatment) : 16Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : aged garlic extract (equivalent to 6-7 cloves of garlic)Duration : 3 monthsType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 1 gram orallyResult : NegativeRemark : A clinical trial of healthy volunteers being administered commercial aged garlic extract (approximately equivalent to six to seven cloves of garlic) for 3 months did not alter the oxidative and glucuronidation metabolism of acetaminophen (1 g orally) but caused a slight increase in sulfation.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl sulfoneType of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) :Result : PositiveRemark : An animal study in mice indicated that garlic - derived diallyl sulfone (DASO2) decreased the plsma concentrations of oxidative acetaminophen metabolites but not of nonoxidative acetaminophen metabolites, due to the inhibition of CYP2E1, which is the major enzyme responsible for the bioactivation of acetaminophen.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl sulfoneType of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 25 mg/kgDuration : 1 h prior to acetaminophen administrationType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : -Result : PositiveRemark : Diallyl sulfone (25 mg/kg), when administered orally 1 h prior to, immediately, or 20 min after a toxic dose of acetaminophen, completely protected mice from the development of hepatotoxicity. A low dose of diallyl sulfone (5 mg/kg), when administered to mice 1 h prior to acetaminophen administration, showed protective effects.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl sulfoneType of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 25 mg/kgDuration : immediately to acetaminophen administrationType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : -Result : PositiveRemark : Diallyl sulfone (25 mg/kg), when administered orally 1 h prior to, immediately, or 20 min after a toxic dose of acetaminophen, completely protected mice from the development of hepatotoxicity. A low dose of diallyl sulfone (5 mg/kg), when administered to mice 1 h prior to acetaminophen administration, showed protective effects.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl sulfoneType of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 25 mg/kgDuration : 20 min after acetaminophen administrationType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : -Result : PositiveRemark : Diallyl sulfone (25 mg/kg), when administered orally 1 h prior to, immediately, or 20 min after a toxic dose of acetaminophen, completely protected mice from the development of hepatotoxicity. A low dose of diallyl sulfone (5 mg/kg), when administered to mice 1 h prior to acetaminophen administration, showed protective effects.Note : Data incomplete, data from review article
Part Used : หัวActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl sulfoneType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 mg/kgDuration : 1 h prior to acetaminophen administrationType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : -Result : PositiveRemark : Diallyl sulfone (25 mg/kg), when administered orally 1 h prior to, immediately, or 20 min after a toxic dose of acetaminophen, completely protected mice from the development of hepatotoxicity. A low dose of diallyl sulfone (5 mg/kg), when administered to mice 1 h prior to acetaminophen administration, showed protective effects.Note : Data incomplete, data from review article
