ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : หัว

Activity : CYP2E1 INHIBITION

Solvent/Active Compound : diallyl sulfone

Type of experiment : in vivo

Type of animal : mouse

Type of study : -

N(Total) :

N(Treatment) :

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacodynamics

Interaction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenol

Dose/Conc.(drug) :

Result : Positive

Remark : An animal study in mice indicated that garlic - derived diallyl sulfone (DASO2) decreased the plsma concentrations of oxidative acetaminophen metabolites but not of nonoxidative acetaminophen metabolites, due to the inhibition of CYP2E1, which is the major enzyme responsible for the bioactivation of acetaminophen.

Note : Data incomplete, data from review article

---