Part Used : หัว
Activity : CYP2C19 INHIBITION
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Cross over
N(Total) : 18
N(Treatment) : 18
Route : Oral administration
Dose/Conc.(herb) : allicin capsule 180 mg once daily
Duration : 14 days
Type of interaction : Pharmacokinetics
Interaction with drug : Omeprazole
Dose/Conc.(drug) : -
Remark : The results of this study demonstrate that allicin reduces the metabolism of omeprazole by inhibiting CYP2C19 activity in healthy Chinese male subjects with the genotype CYP2C19*1/CYP2C19*1 or CYP2C19*1/CYP2C19*2 or*3 but not CYP2C19*2/CYP2C19*2. Allicin did not significantly affect the activity of CYP3A4 in all subjects after 14 days of exposure.
Note : - Eighteen subjects (six CYP2C19*1/CYP2C19*1, four CYP2C19*1/CYP2C19*2, two CYP2C19*1/CYP2C19*3, and six CYP2C19*2/CYP2C19*2)
- On the 15th day, all subjects were given a single oral dose of omeprazole (20 mg capsule) with 250 ml of warm water after an overnight fast.
