| Synonym |
| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl trisulfide (DATS)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : OtherDose/Conc.(herb) : 20 mg/kgDuration : 5 min before the i.v. administration or oral gavage of nifedipineType of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : 0.75 mg/kg, i.v. or 3 mg/kg, oralResult : PositiveRemark : Type of experiment: In the short-term on nifedipine, vehicle (medium chain triglycerides) or DATS (20 mg/kg) was intragastically administered 5 min before the i.v. administration (0.75 mg/kg) or oral gavage of nifedipine (3 mg/kg).Note : Compared to the control groups, higher Cmax and AUC0-24h were observed for oral gavage of nifedipine after short-term and long-term pretreatment of DATS, whereas those for intravenous nifedipine were little changed. The oral bioavailabilities of nifedipine were remarkably enhnaced via the concomitant use of DATS.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : diallyl trisulfide (DATS)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : OtherDose/Conc.(herb) : 20 mg/kgDuration : 15 daysType of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : 0.75 mg/kg, i.v. or 3 mg/kg, oralResult : PositiveRemark : Type of experiment: In long-term administration groups, rats were gavaged once daily for 15 consecutive days with either medium-chain triglycerides (control) or 20 mg/kg DATS in a volume of 2.5 mL/kg. On the morning of day 15, all the animals were gastrogavaged with nifedipine (3 mg/kg) or intravenously administered nifedipine (0.75 mg/kg solution) 5 min after the last administration of DATS.Note : Compared to the control groups, higher Cmax and AUC0-24h were observed for oral gavage of nifedipine after short-term and long-term pretreatment of DATS, whereas those for intravenous nifedipine were little changed. The oral bioavailabilities of nifedipine were remarkably enhnaced via the concomitant use of DATS.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 250 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Garlic homogenate (GH)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) :Result : PositiveRemark : Administration of GH resulted in decrease in LDH and CK-MB activities in serum and increase in heart tissue homogenate (HTH) compared to isoproterenol (ISO) control. The superoxide dismutase and catalase acitivities were found to be increased in all treated groups compared to ISO control. The QRS duration, QT segment and RR intervals were normalized by GH and calcium channel blockers (CCBs) treatments. Among the various combinations, GH 250 mg/kg with diltiazem was substantially more portective than GH with nifedipine/verapamil thereby providing strength to myocardium during stress.Note : Data incomplete
