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Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : diallyl trisulfide (DATS)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : OtherDose/Conc.(herb) : 20 mg/kgDuration : 5 min before the i.v. administration or oral gavage of nifedipineType of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : 0.75 mg/kg, i.v. or 3 mg/kg, oralResult : PositiveRemark : Type of experiment: In the short-term on nifedipine, vehicle (medium chain triglycerides) or DATS (20 mg/kg) was intragastically administered 5 min before the i.v. administration (0.75 mg/kg) or oral gavage of nifedipine (3 mg/kg).Note : Compared to the control groups, higher Cmax and AUC0-24h were observed for oral gavage of nifedipine after short-term and long-term pretreatment of DATS, whereas those for intravenous nifedipine were little changed. The oral bioavailabilities of nifedipine were remarkably enhnaced via the concomitant use of DATS.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : diallyl trisulfide (DATS)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : OtherDose/Conc.(herb) : 20 mg/kgDuration : 15 daysType of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : 0.75 mg/kg, i.v. or 3 mg/kg, oralResult : PositiveRemark : Type of experiment: In long-term administration groups, rats were gavaged once daily for 15 consecutive days with either medium-chain triglycerides (control) or 20 mg/kg DATS in a volume of 2.5 mL/kg. On the morning of day 15, all the animals were gastrogavaged with nifedipine (3 mg/kg) or intravenously administered nifedipine (0.75 mg/kg solution) 5 min after the last administration of DATS.Note : Compared to the control groups, higher Cmax and AUC0-24h were observed for oral gavage of nifedipine after short-term and long-term pretreatment of DATS, whereas those for intravenous nifedipine were little changed. The oral bioavailabilities of nifedipine were remarkably enhnaced via the concomitant use of DATS.
