Part Used : หัว
Activity : PHARMACOKINETIC STUDY OF
Solvent/Active Compound : garlic extract
Type of experiment : human
Type of animal : -
Type of study : non specified
N(Total) : 14 (M/F=9/5)
N(Treatment) : 14
Route : Oral administration
Dose/Conc.(herb) : garlic extract 600 mg tablet, 3 x 600 mg twice daily
Duration : 14 days
Type of interaction : Pharmacokinetics
Interaction with drug : Alprazolam
Dose/Conc.(drug) : -
Remark : The administration of a garlic extract (with an allicin potential of 600 micrograms; alliin, 1.5 mg; and S - allyl - L - cysteine, 0.03 mg in each 600 mg tablet, 3 x 600 mg twice daily) insignificantly increased the ratio of dextromethorphan to its metabolite from 0.044 at baseline to 0.052 (p> 0.05). No significant differences were seen in pharmacokinetic parameters (Cmax, AUC, t1/2) for alprazolam at baseline, and after garlic extract treatment.
Note : Data incomplete, data from review article
