Part Used : ใบ
Activity : CYP3A4 INDUCTION
Solvent/Active Compound : Methanolic extract
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Rifampicin*/Rifampin
Dose/Conc.(drug) : -
Remark : The mRNA expression of P-gp and CYP1A2 was also increased by the extract, alkaloid rich fraction and 4 of the constituents, while the expression of CYP3A4 was increased by the alkaloid rich fraction and 3 of the constituents.