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MALVACEAE Hibiscus sabdariffa L.

Synonym

none ...

Thai / English name

กระเจี๊ยบแดง*

[1-1] of 1 article(s) found

หน้า 1

[1] HERB–DRUG INTERACTION BETWEEN THE EXTRACT OF HIBISCUS SABDARIFFA L. AND HYDROCHLOROTHIAZIDE IN EXPERIMENTAL ANIMALS.
OKECHUKWU O. NDU,CHUKWUEMEKA S. NWORU,CHINWENDU O. EHIEMERE,ET AL.
J MED FOOD 2011 Vol.14(6),640-4 $58255 [Full]

Part Used : ดอก
Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : methanolic

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : HSE 40 mg/kg B.W.

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Hydrochlorothiazide*/HCTZ
Dose/Conc.(drug) : -

Result : Positive

Remark : Route* Intragastric tube - Effect of co-administration of HSE and HCT on diuresis in rats. - Co-administration of the extract (40 mg/kg) with HCT (10 mg/kg) caused a significant increase in the volume of urine excreted, as well as a significant decrease in the pH of urine and the concentrations of sodium bicarbonate and chloride ions.

Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide

Part Used : ดอก
Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : methanolic

Type of experiment : in vivo
Type of animal : rabbit

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : HSE 20 mg/kg B.W.

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Hydrochlorothiazide*/HCTZ
Dose/Conc.(drug) : 10 mg/kg

Result : Positive

Remark : - Effect of HSE on pharmacokinetics of HCT in rabbits. - Increased and prolonged the plasma concentration, the mean area under the concentration-time curve the volumn of distribution of diuretic drug over a 24h sampling period.

Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide

Part Used : ดอก
Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : methanolic

Type of experiment : in vivo
Type of animal : rabbit

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : HSE 40 mg/kg B.W.

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Hydrochlorothiazide*/HCTZ
Dose/Conc.(drug) : 10 mg/kg

Result : Positive

Remark : - Effect of HSE on pharmacokinetics of HCT in rabbits. - Increased and prolonged the plasma concentration, the mean area under the concentration-time curve the volumn of distribution of diuretic drug over a 24h sampling period.

Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide

หน้า 1

EN

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