Part Used : กลีบเลี้ยง
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Cross over
N(Total) : 6
N(Treatment) : 6
Sex : Male
Age : 28.50+/-1.76 years
Route : Oral administration
Dose/Conc.(herb) : sweetened aqueous extract prepared from 30 g dried hibiscus calyces
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenol
Dose/Conc.(drug) : 10 mg/kg
Remark : - In the first phase on oral dose of acetaminophen (1 g) was administered to the volunteer and in the second phases, zobo drink (extract of H. Sabdariffa) was ingested by the volunteers 1.30 h prior the administration of acetaminophen (1 g).
- No significant kinetic changes were observed when the extract was administered concomitanty with acetaminophen, except for a slight elevation of total body clearance (Clt) 11.69%.
Note : - Data from review
- Abbreviation
HSE Hibiscus sabdariffa Extract
HCT hydrochlorothiazide
