Part Used : กลีบเลี้ยง
Activity : DRUG INTERACTION
Solvent/Active Compound : water / anthocyanin
Type of experiment : human
Type of animal : -
Type of study : Open trial
N(Total) : 12
N(Treatment) : 12
Route : Oral administration
Dose/Conc.(herb) : 300 ml (equivalent to 8.18 mg anthocyanins)
Duration : 3 days
Type of interaction : Pharmacokinetics
Interaction with drug : Diclofenac
Dose/Conc.(drug) : 25 mg
Remark : - The diclofenac excreted with co-administration of H. sabdariffa was much lower (0.56+/-0.17 microgram/mL) than with the control (0.90+/-0.50 microgram/mL) with a significant difference observed (p<0.05; 95% confidence interval means - 0.319; 0.037 to 0.602; F=7.069).
Note : - There was a reduction in the amount of diclofenac excreted and the wide variability observed in the control with the water beverage of Hibiscus sabdariffa (p<0.05). There is an increasing need to counsel patients against the use of plant beverages with drugs.